Hierarchical Learning Water Cycle Algorithm

In order to improve the global searching ability of Water Cycle Algorithm (WCA), the hierarchical learning concept is introduced and the Hierarchical Learning WCA (HLWCA) is proposed in this paper. The underlying idea of HLWCA is to divide the solutions into collections and give these collections with hierarchy differences. One of the collections has a higher hierarchy than others and utilizes an exploration-inclined updating mechanism. The solutions in this high hierarchy collection are the exemplars of other collections. The other collections are sorted according to the exemplars’ function value and the solutions in these collections actively choose whether to follow their own exemplar or not. Through different updating mechanisms of collections, the global searching ability is improved while the fast convergence and strong local search ability of WCA are retained. The proposed HLWCA is firstly experimented on IEEE CEC 2017 benchmark suite to testify its performance on complex numerical optimization tasks. Then, it is tested on four practical design benchmark problems to verify its ability of solving real-world problems. The experimental results illustrate the efficiency of the proposed algorithm.     

The Role of Cell Cycle Regulators in Cell Survival—Dual Functions of Cyclin-Dependent Kinase 20 and p21Cip1/Waf1

The mammalian cell cycle is important in controlling normal cell proliferation and the development of various diseases. Cell cycle checkpoints are well regulated by both activators and inhibitors to avoid cell growth disorder and cancerogenesis. Cyclin dependent kinase 20 (CDK20) and p21^Cip1/Waf1 are widely recognized as key regulators of cell cycle checkpoints controlling cell proliferation/growth and involving in developing multiple cancers. Emerging evidence demonstrates that these two cell cycle regulators also play an essential role in promoting cell survival independent of the cell cycle, particularly in those cells with a limited capability of proliferation, such as cardiomyocytes. These findings bring new insights into understanding cytoprotection in these tissues. Here, we summarize the new progress of the studies on these two molecules in regulating cell cycle/growth, and their new roles in cell survival by inhibiting various cell death mechanisms. We also outline their potential implications in cancerogenesis and protection in heart diseases. This information renews the knowledge in molecular natures and cellular functions of these regulators, leading to a better understanding of the pathogenesis of the associated diseases and the discovery of new therapeutic strategies.     

物联网下新型教学模式及全周期培评研究

电气学科工程教育目前面临着新机遇、新挑战，本文拟结合物联网理念及其“感知-传输-应用”三层体系架构，建立电气学科“调研-教学-评价”三层电气教学物联网体系：“感知”即调研，“传输”即教学，“应用”即评价。接着文章构建了电气学科“感知式基础库”，研究了传统+现代的多平台教学模式进行人才培养；最后开展了教学模式的全培养周期学习及评价，以满足学生多元化发展，适应社会及行业的发展需求。     

A new sustainable hydrogen clean energy paradigm

We analyze the feasibility of a novel, hydrogen fuel cell electric generator to provide power with zero noise and emissions for myriad ground based applications. The hydrogen fuel cell electric generator utilizes a novel, scalable apparatus that safely generates hydrogen (H₂) on demand according to a novel method, using a controlled chemical reaction between water (H₂O) and sodium (Na) metal that yields hydrogen gas of sufficient purity for direct use in fuel cells without risk of contaminating sensitive catalysts. The sodium hydroxide (NaOH) byproduct of the hydrogen producing reaction, is collected within the apparatus for later reprocessing by electrolysis, to recover the Na reactant. The detailed analysis shows that the novel, hydrogen fuel cell electric generator will be capable of meeting the clean power requirements for residential and commercial buildings including single family homes and light commercial establishments under a wide range of geographic and climatic conditions.     

Age and productivity as determinants of firm survival over the industry life cycle

This paper contributes to fill the gap between the literature on the determinants of firm survival and the empirical works on the industry life cycle (ILC). Using a representative sample of Spanish firms with 10 or more employees over the period 1993–2009, the role played by firm age and productivity in firm survival is empirically analysed across three stages of the life cycle of forty-seven 3-digit manufacturing sectors. In the ‘early’ stage of the ILC, firm age is negatively correlated with hazard rates while firm productivity is not. Firm productivity is associated with lower hazard in the ‘mature’ stage of the ILC, when competition is primarily efficiency-driven, while firm age does not play a significant role for firm survival. In the ‘intermediate’ stage, both age and productivity play a role in reducing firms’ hazard rates.     

基于二元水循环的水量-水质-水效联合调控模型开发与应用

为将我国最严格水资源管理制度的实践与二元水循环理论相结合，提高“三条红线”控制指标的科学性与合理性，本文以SWAT模型为基础，通过改进子流域划分方法、添加经济社会模块和人工用水模块，对其人工侧支循环模拟进行了系统的完善，开发了基于SWAT的水量-水质-水效联合调控模型SWAT_WAQER。以广西南流江流域为例，从国民经济用水量、河道径流与水质等方面对模型进行校验，并在此基础上划分了2030年“三条红线”控制指标。结果表明：该模型性能良好，能够用于不同节水情景下的国民经济用水量、污染物排放量、水功能区水质达标结果分析，可以作为科学制定“三条红线”控制指标的有力支撑工具。     

Coupling heat storage to nuclear reactors for variable electricity output with baseload reactor operation

Nuclear reactors produce heat and thus can couple to heat storage systems to provide dispacthable electricity while the reactor operates at full power. Six classes of heat storage technologies couple to light-water reactors with steam cycles. Firebrick Resistance-Heated Energy Storage (FIRES) converts low-price electricity into high-temperature stored heat for industry or power. FIRES and brick recuperators coupled to nuclear brayton power cycles may enable high-temperature reactors to buy electricity when prices are low and sell electricity at higher price.     

The relationship between oil prices and US economy revisited

The authors revisit the relationship between US economic growth and crude oil prices considering Industrial Production Index and West Texas Intermediate crude oil spot prices as respective proxies for a period spanning over January 1986 to June 2017. To capture the asymmetric and time-varying relationship, the authors employ maximum overlap discrete wavelet transform (MODWT)-based quantile regression (QR) analysis. Interestingly, MODWT-based QR analysis provides evidence of supply-driven link between crude oil prices and economic growth in the short run. However, in the medium to long run a demand-driven link is dominant. In addition, the QR results without MODWT also advocate a demand-driven link. Overall, the result of this study adds a new dimension to the literature on the relationship between crude oil prices and economic growth by focusing upon the time-frequency varying business cycle fluctuations.     

Quantitative assessments of performance and robustness of maintenance policies for stochastically deteriorating production systems

Over the last few decades, many efforts have been invested in improving the economic performances of maintenance policies for stochastically deteriorating production systems. However, with the development of complex production systems, maintenance managers are interested not only in cost saving, but also in how to trustworthily plan and allocate the required maintenance budget. In this context, the robustness of maintenance policies which is related to the maintenance cost variability from a renewal cycle to another plays a pivotal role. This research deals with a quantitative approach to jointly assess the economic performance and robustness of some representatives of two most well-known classes of maintenance policies: time-based and condition-based maintenance. To this end, we first propose a new cost criterion which combines the long-run expected cost rate and standard deviation of maintenance cost per renewal cycle. Then, we develop and compare the associated mathematical cost models of the considered maintenance policies on the basis of the Gamma degradation process and the theory of stochastic renewal processes. The comparison results under different situations of maintenance costs and system characteristics show that the optimal configuration of maintenance policies gives the best compromise between the performance and robustness, and is mostly affected by the system downtime. Under this aspect, the condition-based maintenance remains more profitable than the time-based maintenance. Still, maintenance managers could implement condition-based maintenance policies that efficiently control the downtime to maximise the maintenance effectiveness of production systems from both performance and robustness viewpoints.     

Betel Nut Arecoline Induces Different Phases of Growth Arrest between Normal and Cancerous Prostate Cells through the Reactive Oxygen Species Pathway

Prostate cancer (PCa) is a reproductive system cancer in elderly men. We investigated the effects of betel nut arecoline on the growth of normal and cancerous prostate cells. Normal RWPE-1 prostate epithelial cells, androgen-independent PC-3 PCa cells, and androgen-dependent LNCaP PCa cells were used. Arecoline inhibited their growth in dose- and time-dependent manners. Arecoline caused RWPE-1 and PC-3 cell cycle arrest in the G2/M phase and LNCaP cell arrest in the G0/G1 phase. In RWPE-1 cells, arecoline increased the expression of cyclin-dependent kinase (CDK)-1, p21, and cyclins B1 and D3, decreased the expression of CDK2, and had no effects on CDK4 and cyclin D1 expression. In PC-3 cells, arecoline decreased CDK1, CDK2, CDK4, p21, p27, and cyclin D1 and D3 protein expression and increased cyclin B1 protein expression. In LNCaP cells, arecoline decreased CDK2, CDK4, and cyclin D1 expression; increased p21, p27, and cyclin D3 expression; had no effects on CDK1 and cyclin B1 expression. The antioxidant N-acetylcysteine blocked the arecoline-induced increase in reactive oxygen species production, decreased cell viability, altered the cell cycle, and changed the cell cycle regulatory protein levels. Thus, arecoline oxidant exerts differential effects on the cell cycle through modulations of regulatory proteins.